HEALTH MANAGEMENT. Study suggests that the 'Dirty' wild mice may be relevant Immunology model

Like humans, mice, the life in their natural habitat meeting be bacteria and other pathogens, which exert their immune system still the lab mice, typically in Immunology studies in triggered to most diseases. A study on natural killer cells in wild mice, who this week published the hypothesis that the operational lives of people facing and wild the willingness of the immune system can improve mice, studied in molecular ecology to combat new infections. The results indicate that the neglected traditional lab mouse model environmental factors research, that are required to fully represent the immune system of mice and men.
Natural killer (NK) cells are key players in the development of important immune system response to vaccines, infection, or cancer. However essential NK cell actions take place in the lymph nodes, and NK cells are usually not seen in lab mouse lymph nodes, if the animal is exposed to an infection. People and animals, on the other hand, port NK-cells in their lymph nodes at all times. Preben Boysen and colleagues at the Norwegian School of veterinary science and the Norwegian Institute of public health found that wild lymph nodes had mice also increased number of NK-cells, which in comparison with laboratory mice, suggesting that these wild mice human immune system more accurate than lab-mouse-based Immunology studies meet.
These results are a recently proposed hypothesis, that NK-cells need a microbial primer phase to be consistent. The increased activity of NK cell in wild mice could also the recent discoveries, NK cells carry imprints of previous microbial meets and remain for a long time as "Memory-like" cells, the previous presentation, that such cells usually ephemeral reflect immune cells. An important interpretation of these results is that the immunological research in the conventional mouse model may be important NK immune responses Miss is based, because these key cellular players will have gone through not the microbial primer, occur typically in a mouse or a human nature.

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