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Jumat, 14 Oktober 2011

In African Cave, An Early Human Paint Shop

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This abalone shell was found with ocher and a grinding stone. The iron oxide was used as a pigment to paint bodies and walls, as well as to thicken glue. Enlarge Science/AAAS

This abalone shell was found with ocher and a grinding stone. The iron oxide was used as a pigment to paint bodies and walls, as well as to thicken glue.

This abalone shell was found with ocher and a grinding stone. The iron oxide was used as a pigment to paint bodies and walls, as well as to thicken glue. Science/AAAS

This abalone shell was found with ocher and a grinding stone. The iron oxide was used as a pigment to paint bodies and walls, as well as to thicken glue.

Apparently one of the earliest human instincts was to paint things, including bodies and cave walls. That's the conclusion from scientists who have discovered something remarkable in a South African cave — a tool kit for making paint. It looks to be the oldest evidence of paint-making.

Over in southern Africa 100,000 years ago, Homo sapiens was pretty new on the scene. A favorite hangout was a cave named Blombos near the Southern ocean.

Archaeologists like Christopher Henshilwood have spent decades finding stuff there that our ancestors left behind. Recently, Henshilwood uncovered two abalone shells with ocher ground into the shell. "Above and below each shell and to the side of each shell was a complete kit that was used for producing a pigmented mixture," he says.

In addition to the shells were stone flakes, grinding stones and bits of bone with reddish ocher on them. Ocher is a kind of iron oxide dug from the ground that early humans used as a pigment and to thicken glue.

I think we're going to find that these early people were smarter than we think.

- Alison Brooks, anthropologist, The George Washington University

Henshilwood, a professor with the University of the Witwatersrand in South Africa and the University of Bergen in Norway, says his discovery points to decoration.

"I think the most likely explanation for this is that they were producing paint," he says. "This really was the smoking gun."

Henshilwood says for a short time, the cave was a paint shop — the earliest ever seen. The makers added bone and charcoal to a liquid mixture to make it oily and viscous so it would stick. The ocher provided color and a matrix. It was complex chemistry but stirred by hand.

"We can see where the small quartz grains that had adhered to the finger had left a very tiny trace in the shell," Henshilwood says.

Archaeologist Christopher Henshilwood excavates at the 100,000-year-old levels of the Blombos cave in South Africa. Enlarge Science/AAAS

Archaeologist Christopher Henshilwood excavates at the 100,000-year-old levels of the Blombos cave in South Africa.

Archaeologist Christopher Henshilwood excavates at the 100,000-year-old levels of the Blombos cave in South Africa. Science/AAAS

Archaeologist Christopher Henshilwood excavates at the 100,000-year-old levels of the Blombos cave in South Africa.

Higher-Order Thinking

In a laboratory at George Washington University, anthropology student Andrew Zipkin opens a bag of ocher and puts it into a mortar, where he grinds it with a pestle.

"You need to sort of tap it and break it up first," he explains. "The finer-grain material here is quite powdery now. This is ready to use. I can mix this with water and I'll have a pretty nice paint out of this."

Zipkin's Ph.D. work focuses on ocher and how to make stuff with it the way ancient humans did.

Lately, he has been exploring the other ancient use for ocher: He's gluing stone points onto arrowheads. Then he tests how well the glue works.

"I went to an Ethiopian butcher in Falls Church, Va., and tracked down a goat carcass they had there," he says. Then he shot the arrows into the carcass. He found that the arrowheads with ocher stayed on better than those without.

Researchers found paint and tools in the Blombos cave, marked with the white arrow on the left side of the image, on the southern coast of South Africa. Enlarge Magnus Haaland

Researchers found paint and tools in the Blombos cave, marked with the white arrow on the left side of the image, on the southern coast of South Africa.

Researchers found paint and tools in the Blombos cave, marked with the white arrow on the left side of the image, on the southern coast of South Africa. Magnus Haaland

Researchers found paint and tools in the Blombos cave, marked with the white arrow on the left side of the image, on the southern coast of South Africa.

Zipkin makes a lot of ocher mixtures — you can tell by looking at his hands and his clothes. He says the recipe has to be followed exactly right, a process that takes planning.

"I think we're going to find that these early people were smarter than we think," says Alison Brooks, an anthropologist at George Washington University. She says working with ocher reflects higher-order thinking, and using it as paint probably represents an early form of symbolic thinking as well.

"The ultimate purpose of putting something on yourself, your house, your walls is to make a statement about who you are," she says. "So it would have been important to identify yourself as a friend."

Whoever these people were — primitive Picassos or house painters — their handiwork lasted 100,000 years, and is described in the journal Science.

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Author Thomas Thwaites discusses his quest to build a toaster from scratch, starting with iron ore.

The YouTube Space Lab contest asks students to submit their space-based science experiment ideas.

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Sabtu, 08 Oktober 2011

Scientists hail gain in human embryonic stem cell research

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The achievement is an "important step" in stem cell research, scientists say They used a technique similar to the one used to clone Dolly the sheepThe motivation for the research was to eventually cure diseases such as Parkinson's, diabetes

(CNN) -- For the first time, researchers have succeeded in creating human embryonic stem cells by injecting DNA from a skin cell into an unfertilized egg, according to a study published Wednesday.

To achieve what is being called an "important step" in stem cell research, scientists in New York used a cloning technique similar to the one used to clone Dolly the sheep.

"This work now demonstrates for the first time that the human egg has the ability to turn a specialized cell into a stem cell," said Dieter Egli, who along with fellow study author Scott Noggle led the research team at the New York Stem Cell Foundation.

"The goal of this research was to create patient-specific embryonic stem cells with the patients' DNA for the eventual use in cell replacement therapy," Egli told CNN.

He said the motivation for the research was to eventually cure diseases such as Parkinson's, diabetes and many other illnesses.

In 2005, researchers in South Korea claimed to have created the first human embryonic stem cells by cloning an embryo. A year later, it was revealed that the data had been faked.

This new study, published in the journal Nature, shows researchers have finally succeeded in creating human embryonic stem cells. They weren't perfect though because they have too many chromosomes -- 69 instead of the usual 46 -- making the cells suitable for research purposes only, not actual treatments.

In the past, efforts to create human stem cells using cloning meant taking an unfertilized egg, removing egg's nucleus with its 23 chromosomes and replacing it with the nucleus of a skin cell (which has 46 chromosomes) and placing the egg in a chemical bath to make it divide as if it had been fertilized by sperm.

Researchers started out with 270 donated oocytes or unfertilized eggs, provided by sixteen egg donors, Noggle said.

Egli said through a process of elimination, he and his colleagues determined that it was the removal of the egg's genome, not the introduction of new DNA or chemically initiating cell division, which was preventing the egg to develop far enough along so stem cells can be extracted. Noggle says 63 eggs were needed to develop two cell lines, of which one was viable.

"It's the machinery within the egg that allows the egg to progress normally in development," said Ted Golos, who is a professor of Comparative Biosciences at the school of Veterinary Medicine at the University of Wisconsin-Madison.

Golos, who is not involved in this new research, says this new study isn't a giant leap forward but it's an interesting one. Now the challenge is to figure out how to remove the egg's chromosomes, without removing the machinery or spindle, which helps the egg divide. Egli said he and his colleagues are working on just that.

Researchers have been using adult stem cells like bone marrow for treatments for decades. But adult stem cells have been programmed for one part of the body and are not easily converted to correcting problems in other parts of the body.

Then the first major advance in human embryonic stem cell research came In 1998, when Jamie Thomson at the University of Wisconsin-Madison, extracted the first stem cells from an existing human embryo.

In 2007, researchers in Japan and California reported the creation of stem cells by bypassing eggs altogether and reprogramming skin cells directly into dividing like fertilized eggs with the addition of four viruses.

These cells are called induced pluripotent stem cells or iPS cells. Since then, researchers have found these cells have some limitations as well. While some opponents of embryonic research believe advances in the "less controversial" adult stem cell and iPS cells eliminate the need for embryonic stem cell research, most experts in the field believe all three research paths need to be explored to eventually find the right treatment for the right disease.

Dr. Alan Trounson, who heads the California Institute for Regenerative Medicine, which funds embryonic and adult stem cell research, says if researchers are able to take the next step and figure out how to make embryonic stem cells without the excess chromosomes, then they can begin to compare them to iPS cells and determine how different or similar they really are.

Egli agrees.

"We need to better understand the biology of the human egg for reprogramming without the egg genome," he said.



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Researchers Advance Cloning Of Human Embryos

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Researchers in New York are reporting an advance in creating cloned human embryos. The embryos would not be used for reproduction, but rather for the creation of embryonic stem cells. Many scientists believe that human embryonic stem cells made this way could revolutionize medicine.

The advantage of stem cells made this way is that they could be personalized to an individual.

[Egli's work] isn't the gold ring, but it's a major step forward.

- George Daley, stem-cell researcher, Children's Hospital Boston

Think of it this way: Let's say you know you're going in for surgery in a few months to have your hip replaced. The surgeon says you may lose blood during the surgery, and recommends that you donate a pint of your own blood in advance in case you need it during the operation.

The advantage of donating your own blood is that there's no chance your immune system will reject that blood if it's put back into you.

Cloning, or somatic cell nuclear transfer, as scientists prefer to call it, is a technique that allows you to make what is essentially a genetic copy of a living organism. Stem cells derived from a cloned embryo are made with one of your stem cells but will be genetic twins to all the cells in your body, so receiving a stem-cell transplant would essentially mean getting your own cells back.

Dieter Egli and his colleagues at the New York Stem Cell Foundation have taken an important step toward that goal.

First they took an egg, removed its genetic material, replaced it with the genetic material from an adult skin cell, and coaxed the resulting embryo to grow. This is basically the same technique Scottish scientists used to create the first cloned mammal, Dolly the sheep. (See the top path in the illustration below.)

But Egli says that just because something works in some mammals doesn't mean it necessarily has to translate to human cells. And as others have found in the past, embryos made this way wouldn't grow.

Then Egli modified the Dolly technique. He left in the egg's genetic material instead of removing it, and then added the genetic material from the adult cell. That did the trick. The embryo started growing. (See the bottom path in the illustration below.)

In a first attempt (top), researchers removed an egg's genetic material and replaced it with the genes from an adult skin cell. These embryos didn't grow. The researchers tried another method: They left the egg's original genetic material in, but then also added genetic material from an adult cell (bottom). These embryos started growing. Nature

In a first attempt (top), researchers removed an egg's genetic material and replaced it with the genes from an adult skin cell. These embryos didn't grow. The researchers tried another method: They left the egg's original genetic material in, but then also added genetic material from an adult cell (bottom). These embryos started growing.

But there was a problem.

Leaving in the egg's DNA meant each cell in the embryo now had three sets of chromosomes, instead of the two that are normally there. Transplanting stem cells derived from these embryos as a medical therapy wouldn't work. Our bodies just wouldn't know what to do with three sets of chromosomes.

This image shows the chromosomes from one of the cloned cells. Notice there are three sets of each chromosome; normal cells have just two copies of each chromosome. Nature

This image shows the chromosomes from one of the cloned cells. Notice there are three sets of each chromosome; normal cells have just two copies of each chromosome.

But at least Egli has answered the question of whether it's possible to make a cloned human embryo. "The clear answer of our paper to this is yes, and this is really the major finding of the paper," he says.

Egli says this result gives him the confidence to keep working with their approach, to see if they can make it work with just the two chromosomes that are supposed to be there.

"[Egli's work] isn't the gold ring, but it's a major step forward, says stem-cell researcher George Daley, who works at Children's Hospital in Boston.

But even if Egli perfects his cloning techniques, there are still many people morally opposed to this kind of research. Daley says a new kind of cell, called an iPS cell, may prove to be just as good as an embryonic stem cell, and iPS cells can be made without eggs or embryos.

"The jury is still out as to whether the iPS cells are going to be the gold standard in the long run. In the near term, it's still the embryo-derived stem cells," says Daley. So for now, he thinks work with cloned human embryos should continue.

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All Things Considered–

The 2011 Nobel Prize in Physics has gone to three American astronomers.

Two engineers are videoing fire with high speed cameras to reconstruct a flame in 3D.

In The Better Angels of Our Nature, Steven Pinker argues that violence is decreasing.



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Jumat, 07 Oktober 2011

Researchers Advance Cloning Of Human Embryos

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Researchers in New York are reporting an advance in creating cloned human embryos. The embryos would not be used for reproduction, but rather for the creation of embryonic stem cells. Many scientists believe that human embryonic stem cells made this way could revolutionize medicine.

The advantage of stem cells made this way is that they could be personalized to an individual.

[Egli's work] isn't the gold ring, but it's a major step forward.

- George Daley, stem-cell researcher, Children's Hospital Boston

Think of it this way: Let's say you know you're going in for surgery in a few months to have your hip replaced. The surgeon says you may lose blood during the surgery, and recommends that you donate a pint of your own blood in advance in case you need it during the operation.

The advantage of donating your own blood is that there's no chance your immune system will reject that blood if it's put back into you.

Cloning, or somatic cell nuclear transfer, as scientists prefer to call it, is a technique that allows you to make what is essentially a genetic copy of a living organism. Stem cells derived from a cloned embryo are made with one of your stem cells but will be genetic twins to all the cells in your body, so receiving a stem-cell transplant would essentially mean getting your own cells back.

Dieter Egli and his colleagues at the New York Stem Cell Foundation have taken an important step toward that goal.

First they took an egg, removed its genetic material, replaced it with the genetic material from an adult skin cell, and coaxed the resulting embryo to grow. This is basically the same technique Scottish scientists used to create the first cloned mammal, Dolly the sheep. (See the top path in the illustration below.)

But Egli says that just because something works in some mammals doesn't mean it necessarily has to translate to human cells. And as others have found in the past, embryos made this way wouldn't grow.

Then Egli modified the Dolly technique. He left in the egg's genetic material instead of removing it, and then added the genetic material from the adult cell. That did the trick. The embryo started growing. (See the bottom path in the illustration below.)

In a first attempt (top), researchers removed an egg's genetic material and replaced it with the genes from an adult skin cell. These embryos didn't grow. The researchers tried another method: They left the egg's original genetic material in, but then also added genetic material from an adult cell (bottom). These embryos started growing. Nature

In a first attempt (top), researchers removed an egg's genetic material and replaced it with the genes from an adult skin cell. These embryos didn't grow. The researchers tried another method: They left the egg's original genetic material in, but then also added genetic material from an adult cell (bottom). These embryos started growing.

But there was a problem.

Leaving in the egg's DNA meant each cell in the embryo now had three sets of chromosomes, instead of the two that are normally there. Transplanting stem cells derived from these embryos as a medical therapy wouldn't work. Our bodies just wouldn't know what to do with three sets of chromosomes.

This image shows the chromosomes from one of the cloned cells. Notice there are three sets of each chromosome; normal cells have just two copies of each chromosome. Nature

This image shows the chromosomes from one of the cloned cells. Notice there are three sets of each chromosome; normal cells have just two copies of each chromosome.

But at least Egli has answered the question of whether it's possible to make a cloned human embryo. "The clear answer of our paper to this is yes, and this is really the major finding of the paper," he says.

Egli says this result gives him the confidence to keep working with their approach, to see if they can make it work with just the two chromosomes that are supposed to be there.

"[Egli's work] isn't the gold ring, but it's a major step forward, says stem-cell researcher George Daley, who works at Children's Hospital in Boston.

But even if Egli perfects his cloning techniques, there are still many people morally opposed to this kind of research. Daley says a new kind of cell, called an iPS cell, may prove to be just as good as an embryonic stem cell, and iPS cells can be made without eggs or embryos.

"The jury is still out as to whether the iPS cells are going to be the gold standard in the long run. In the near term, it's still the embryo-derived stem cells," says Daley. So for now, he thinks work with cloned human embryos should continue.

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All Things Considered– Initially, Daniel Shechtman's discovery cost him a job and the respect of his colleagues.

Initially, Daniel Shechtman's discovery cost him a job and the respect of his colleagues.

The embryos would not be used for reproduction, but rather for the creation of embryonic stem cells.

The embryos would not be used for reproduction, but rather for the creation of embryonic stem cells.

Guy Raz talks with Insoo Hyun, associate professor of bioethics at Case Western Reserve University.



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Human 'cloning' makes stem cells

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5 October 2011 Last updated at 18:04 GMT By James Gallagher Health reporter, BBC News Lead scientist Dr Dieter Egli: "Research gives hope for making cells to cure human disease in the future"

A form of cloning has been used to create personalised embryonic stem cells in humans, say researchers.

Genetic material was taken from an adult skin cell and transferred into a human egg. This was grown to produce an early embryo.

Stem cells have huge potential in medicine as they can transform into any other cell type in the body.

However, the stem cells formed contained chromosomes from both the adult and the egg cells.

The technique used - somatic cell nuclear transfer - shot to fame in 1997 when Dolly the sheep, the first mammal to be cloned from an adult cell, was unveiled to the world.

A South Korean scientist, Hwang Woo-suk, had claimed to have created stem cells from cloned human embryos, but was found to have faked the evidence.

The lead researcher at the New York Stem Cell Foundation Laboratory, Dr Dieter Egli, said there was "a great question mark" about whether the cloning technique could be reliably used in humans.

Dolly the sheep Dolly the sheep

He said other "groups had tried before, but failed".

Writing in the journal Nature, he said his group had also failed using traditional techniques.

When they removed the genetic material from the egg and replaced it with the chromosomes from a skin cell, the egg divided but failed to go past the 6-12 cell stage.

However, when they left the egg's own genetic material in place and added the skin chromosomes, the egg developed. It reached the blastocyst stage, which can contain up to 100 cells and is the usual source of embryonic stem cells.

Stem cell techniques

Eggs and sperm both have one set of chromosomes, which combined means adults have two copies of each chromosome.

In this technique the two adult copies are added to the single copy in the egg meaning a total of three, which can be problematic.

Continue reading the main story

Many diseases are impossible to treat. As the researchers put it they "cannot be cured, they can only be cared for".

Stem cells are one of the great hopes of medicine because they can turn into any other type of cell - nerve, heart, bone, skin, liver etc.

Create heart cells and it might be possible to repair the damage from a heart attack. Insulin-producing cells are destroyed in patients with type 1 diabetes, but stem cells could one day be used to grow more.

There are already clinical trials taking place. The first embryonic stem cell trial in Europe, testing a treatment for progressive sight loss, has started in London.

However this does not use the patient's own cells. Immunosuppressant drugs are likely to be needed to prevent rejection. This is why making stem cells from the body's own cells is seen as such a gold standard of medicine.

Often embryos without the correct number of chromosomes do not develop at all. Down's syndrome is caused by three copies of just one chromosome.

Researchers will need to produce embryonic cells which have only donor DNA, however, once the egg starts to divide the chromosomes are combined in the nucleus and would be near impossible to separate.

Dr Egli told the BBC: "The cells we have made are not yet for therapeutic use. There is clearly more work to be done, this is early days.

"We see this as a step on that road, so now we do know that a human egg can turn an adult specialised cell, such as a skin cell, into a stem cell."

Prof Mary Herbert, from the Institute for Ageing and Health at Newcastle University, said: "This study shows that the conventional approach to somatic cell nuclear transfer is inefficient in humans.

"However, the authors were able to increase the efficiency by leaving the host oocyte [egg] genome in place.

"While this approach does not in itself provide a solution, it takes us a step closer to understanding where the problems lie."

No embryos required

Recently a different route to stem cells has been used. Instead of using an egg, a chemical bath "reprogrammes" an adult cell into a stem cell.

While this is seen as more ethical, there are concerns about whether such cells could be used therapeutically. There are differences between embryonic and "induced" stem cells, with the latter being more prone to expressing cancer causing genes.

Prof Robin Lovell-Badge, from the UK National Institute for Medical Research, said: "This paper will be seen as significant both by those who are trying to use somatic cell nuclear transfer to produce human patient-specific embryonic stem cell lines and by those who oppose human 'cloning' experiments."



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Kamis, 22 September 2011

Christians Divided Over Science Of Human Origins

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Barbara Bradley Hagerty, religion correspondent, NPR
Daniel Harlow, religion professor, Calvin College
Albert Mohler, president, Southern Baptist Theological Seminary

The story of Adam and Eve is a primary belief for many Christians. Some Christian scholars argue that research on the human genome shows that modern humans did not descend from the Biblical couple, and that Christianity must find a way to reconcile modern science and religious beliefs.

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Disagreement over the science of human origins is creating tension within the Christian faith.

Guests got to see a photo exhibit of children from more than 160 countries who live in New York.

A Roman Catholic monastery in North Dakota is putting its ranching operation out to pasture.



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