Target heart, improve sex life?

AppId is over the quota
AppId is over the quota
Nearly 1 in 5 men in the U.S. has difficulty achieving or maintaining an erectionErectile dysfunction is also a known harbinger of heart diseaseDoctors should inform the public of this connection, researchers sayExercise is key for heart health and blood vessel function

(Health.com) -- Middle-aged men who take steps to improve their heart health by eating better, getting more exercise, or taking cholesterol-lowering drugs may end up improving their sex lives as well, according to a new analysis of existing research.

Nearly 1 in 5 men in the U.S. has difficulty achieving or maintaining an erection, a condition known as erectile dysfunction (ED). The new study, which appears this week in the Archives of Internal Medicine, suggests that ED drugs such as Viagra aren't the only solution and aren't always enough to address the problem, says coauthor Dr. Stephen Kopecky, M.D., a cardiologist at the Mayo Clinic in Rochester, Minnesota.

"If you do take care of your lifestyle—eating right, exercising, losing weight—you respond much better to the Viagra, the Levitra, the Cialis," Kopecky says. By the same token, he adds, if these drugs become less effective "that should be a sign that...you need to take care of your lifestyle.'"

Health.com: 7 ways to treat erectile dysfunction

ED is troubling enough by itself, but to make matters worse it's also a known harbinger of heart disease. The arteries in the penis that expand during an erection can become weakened and clogged with cholesterol in the same way as the arteries that surround the heart. This is why ED often shows up three to five years ahead of life-threatening cardiovascular problems such as heart attack or stroke, especially in younger men, Kopecky says.

"The common denominator is blood flow," he explains. "If you look at a guy in his 40s who has erectile dysfunction and then you compare [him] to another guy in his 40s who doesn't have erectile dysfunction, the guy with ED is about 50 times more likely to have heart disease."

Despite this well-established link, there has been little research into whether addressing risk factors for heart disease (such as unhealthy cholesterol numbers) can also reverse ED. The studies that have been conducted have been relatively small and have looked at a single location, which means they may not apply to the population as a whole, Kopecky and his colleagues say.

Health.com: 10 heart-healthy rules to live by

To clarify the effect of heart-healthy lifestyle changes on ED, the researchers combed through the medical literature for placebo-controlled clinical trials in which men with ED modified their lifestyles or began taking cholesterol-lowering statin medications. The analysis was funded entirely by the Mayo Clinic.

In the end they focused on six studies that included a total of 740 men and were conducted in the U.S., Italy, Nigeria, and Iran. In all of the studies, which ranged in length from two months to two years, heart healthy regimens and better cholesterol numbers were associated with modest but measurable improvements on a survey that rates erectile function on a scale from 5 to 25.

The average improvement in sexual function seen in the pooled studies was three points, one point shy of the threshold experts consider "clinically important." For some men, especially those with more persistent cases of ED, a change of that magnitude would be negligible. For those with mild or occasional ED, however, it would translate into noticeable improvements in sexual function, the researchers say.

Health.com: Erectile dysfunction? Try losing weight

Dr. Kevin Billups, M.D., an associate professor of urology at the University of Minnesota, in Minneapolis, says that the close relationship between heart health and sexual function "hasn't become the public health message that it should be."

Doctors and other experts need to do a better of job of informing the public that a healthier heart often means better erections, adds Billups, who studies the link between heart health and erectile function but did not participate in the new research.

"That's the first thing I talk about with all the guys that come in now," he says, referring to the ED patients he sees in his urology practice. "'Are you watching your diet? What kind of exercise program are you on?' Just putting these men on the ED medications...probably isn't enough to get optimal results."

Health.com: The best foods for your heart

Even if they're told that it may improve their ED, getting men to change their lifestyle and lose weight is no easy task, Kopecky says. He stresses, however, that even small and simple lifestyle changes—such as eating at least five servings of fruits and veggies daily—can make a big difference.

But the "real key" is exercise, Kopecky says. Just 10 minutes of vigorous exercise three times a week "does a whole lot to improve your heart function [and] blood vessel function," he says.

Copyright Health Magazine 2010

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HEALTH MANAGEMENT. Target heart, improve sex life?

Nearly 1 in 5 men in the U.S. has difficulty achieving or maintaining an erectionErectile dysfunction is also a known harbinger of heart diseaseDoctors should inform the public of this connection, researchers sayExercise is key for heart health and blood vessel function
(Health.com) -- Middle-aged men who take steps to improve their heart health by eating better, getting more exercise, or taking cholesterol-lowering drugs may end up improving their sex lives as well, according to a new analysis of existing research.
Nearly 1 in 5 men in the U.S. has difficulty achieving or maintaining an erection, a condition known as erectile dysfunction (ED). The new study, which appears this week in the Archives of Internal Medicine, suggests that ED drugs such as Viagra aren't the only solution and aren't always enough to address the problem, says coauthor Dr. Stephen Kopecky, M.D., a cardiologist at the Mayo Clinic in Rochester, Minnesota.
"If you do take care of your lifestyle—eating right, exercising, losing weight—you respond much better to the Viagra, the Levitra, the Cialis," Kopecky says. By the same token, he adds, if these drugs become less effective "that should be a sign that...you need to take care of your lifestyle.'"
Health.com: 7 ways to treat erectile dysfunction
ED is troubling enough by itself, but to make matters worse it's also a known harbinger of heart disease. The arteries in the penis that expand during an erection can become weakened and clogged with cholesterol in the same way as the arteries that surround the heart. This is why ED often shows up three to five years ahead of life-threatening cardiovascular problems such as heart attack or stroke, especially in younger men, Kopecky says.
"The common denominator is blood flow," he explains. "If you look at a guy in his 40s who has erectile dysfunction and then you compare [him] to another guy in his 40s who doesn't have erectile dysfunction, the guy with ED is about 50 times more likely to have heart disease."
Despite this well-established link, there has been little research into whether addressing risk factors for heart disease (such as unhealthy cholesterol numbers) can also reverse ED. The studies that have been conducted have been relatively small and have looked at a single location, which means they may not apply to the population as a whole, Kopecky and his colleagues say.
Health.com: 10 heart-healthy rules to live by
To clarify the effect of heart-healthy lifestyle changes on ED, the researchers combed through the medical literature for placebo-controlled clinical trials in which men with ED modified their lifestyles or began taking cholesterol-lowering statin medications. The analysis was funded entirely by the Mayo Clinic.
In the end they focused on six studies that included a total of 740 men and were conducted in the U.S., Italy, Nigeria, and Iran. In all of the studies, which ranged in length from two months to two years, heart healthy regimens and better cholesterol numbers were associated with modest but measurable improvements on a survey that rates erectile function on a scale from 5 to 25.
The average improvement in sexual function seen in the pooled studies was three points, one point shy of the threshold experts consider "clinically important." For some men, especially those with more persistent cases of ED, a change of that magnitude would be negligible. For those with mild or occasional ED, however, it would translate into noticeable improvements in sexual function, the researchers say.
Health.com: Erectile dysfunction? Try losing weight
Dr. Kevin Billups, M.D., an associate professor of urology at the University of Minnesota, in Minneapolis, says that the close relationship between heart health and sexual function "hasn't become the public health message that it should be."
Doctors and other experts need to do a better of job of informing the public that a healthier heart often means better erections, adds Billups, who studies the link between heart health and erectile function but did not participate in the new research.
"That's the first thing I talk about with all the guys that come in now," he says, referring to the ED patients he sees in his urology practice. "'Are you watching your diet? What kind of exercise program are you on?' Just putting these men on the ED medications...probably isn't enough to get optimal results."
Health.com: The best foods for your heart
Even if they're told that it may improve their ED, getting men to change their lifestyle and lose weight is no easy task, Kopecky says. He stresses, however, that even small and simple lifestyle changes—such as eating at least five servings of fruits and veggies daily—can make a big difference.
But the "real key" is exercise, Kopecky says. Just 10 minutes of vigorous exercise three times a week "does a whole lot to improve your heart function [and] blood vessel function," he says.

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HEALTH MANAGEMENT. Enzyme could be target for the treatment of smoking, alcoholism at the same time

An enzyme that is displayed, a role in controlling the brain response to nicotine and alcohol in mice may be a promising a drug, which would at the same time deal with smoking, and alcohol abuse in humans, according to a study by researchers of the Ernest Gallo clinic and Research Center, San Francisco joined with the University of California,.
In the course of four weeks mice genetically so is missing the gene for protein kinase C (PKC)-Epsilon consumes less a nicotine-containing water solution than normal mice and were less likely to a Chamber back, in which she had given nicotine.
On the other hand, normal mice steadily grew their consumption of nicotine solution, while the mice PKC Epsilon is not missing.
The study was conducted by Gallo, senior associate director and investigator Robert O. brass, MD, UCSF Professor of Neurology and Gallo researchers Dr. Anna M. Lee.
Binds nicotine to a certain class of Nicotinic Receptors in normal mice, as in humans is neurons released by dopamine in the brain causes on dopamine. Dopamine creates a feeling of joy and so calls for a sense of reward. Lee and brass found that mice without PKC Epsilon has a lack of these Nicotinic Receptors.
The study is in the online early Edition of the proceedings of the National Academy of Sciences for the week of 12 September 2011.
The finding complements earlier research in brass found that mice genetically PKC-Epsilon enzyme deficiency to less alcohol than normal mice potion and were averse to a Chamber, where she had been alcohol again.
"This could mean that these mice of nicotine or alcohol, not the same feeling of reward get," brass said. "The enzyme looks like it the part of regulating the reward system, which includes these Nicotinic Receptors." The reward system is a complex of areas in the brain, which call for nicotine, to influence alcohol and other addictive substances.
The next step in the research, brass, said would be to develop compounds that inhibit PKC Epsilon. The ultimate goal, he said, would be drugs, which could be used "through its contribution to the edge of searches for people on some of which will demand their reward."
The research was U.S. through grants from the public health service and the Canadian Institutes of health research, and funded, supported by California for medical research on alcohol and drug abuse by UCSF.
The UCSF-affiliated Ernest Gallo clinic and Research Center is one of the world's preeminent academic centres for the study of the biological basis of alcohol and substance use. Gallo center discoveries possible molecular targets for the development of therapeutic medicines through preclinical and proof-of-concept studies extended.
UCSF is a leading University, promoting health worldwide through advanced biomedical research, graduate training in life sciences and health professions, and excellence in patient care.

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