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Tampilkan postingan dengan label screening. Tampilkan semua postingan
Tampilkan postingan dengan label screening. Tampilkan semua postingan

Minggu, 04 Desember 2011

Medicare Will Cover Obesity Screening and Treatment

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Medicare, which covers some 42 million American seniors, will pay for obesity screening and behavioral therapy as part of its portfolio of preventive services.

About 72 million American adults, including about a third of Medicare recipients, are obese, and the related health-care costs total some $325 billion a year. The federal decision will now allow Medicare beneficiaries to see their doctors for regular weight-loss counseling — a low-cost, low-tech solution — and may spur private insurers to do the same.

According to the Centers for Medicare and Medicaid Services' decision summary, obese Medicare beneficiaries — with a body mass index of 30 or higher — seeking weight-loss counseling may see their primary care physician for one face-to-face visit every week for the first month. Then, Medicare will pay for one face-to-face visit every other week for the next five months. If the patient loses at least 3 kg (6.6 lbs.) over the first six months, Medicare will pay for an additional six months of once-a-month face-to-face visits with the doctor.

MORE: Number of Normal-Weight Americans Edges Out the Overweight

Despite the overwhelming rates of obesity in this country, few people have been diagnosed with a weight problem by their primary care physicians. In a 2007 Mayo Clinic study of nearly 10,000 primary care patients, about one quarter were obese; of those, only about 1 in 5 had a diagnosis or treatment plan for obesity. For older patients, the rate was even lower.

As the Los Angeles Times reported:

While research finds that physician counseling can be a powerful prod to weight loss for those who need it, many physicians have been reluctant to offer it. While some of that reluctance has stemmed from an absence of insurance reimbursement for such services, many also cite patient pushback and a lack of effective tools as reasons for shrinking from the task of identifying obesity, counseling patients about its health hazards and getting them started on a weight-loss program.

Medicare coverage isn't going to change the fact that we still don't have foolproof tools to help people lose weight, or that patients will push back — no one likes to hear that they're obese, after all — but if the federal decision helps lead to more obese people losing even small or moderate amounts of weight, it could be life-changing.

"As small of a weight loss as 5% to 7% can lead to a huge health improvement," Christy Ferguson, director of the STOP Obesity Alliance, told USA Today, noting also that obesity programs should emphasize an overall healthy lifestyle as well as weight loss. "It's not necessarily weight loss so much as it is increased fitness level and increased health."

The coverage is effective immediately, so Medicare recipients may be screened as soon as their next appointment.

Meredith Melnick is a reporter at TIME. Find her on Twitter at @MeredithCM. You can also continue the discussion on TIME's Facebook page and on Twitter at @TIME.



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Rabu, 09 November 2011

Hit reset on cancer screening: 'Tests not perfect'

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WASHINGTON (AP) — It turns out that catching cancer early isn't always as important as we thought.

Some tumors are too slow-growing to ever threaten your life. Some are so aggressive that finding them early doesn't make much difference. And today's treatments are much better for those somewhere in the middle.

Those complexities are changing the longtime mantra that cancer screening will save your life. In reality, it depends on the type of cancer, the test and who gets checked when.

"We can find cancer early. We can reduce the burden of the disease. But along the way, we're learning our tests are not as perfect as we'd like," says the American Cancer Society's Dr. Len Lichtenfeld, a longtime screening proponent. "We're learning that we're now finding cancer that would in fact never cause harm."

Now cancer specialists are struggling to find a new balance: to quit over-promising the power of early detection and to help people understand that the tests themselves have risks — while not scaring away those who really need it.

Least controversial are cervical and colorectal cancer screenings. They can spot pre-cancerous growths that are fairly easy to remove, although even some of those tests can be used too frequently. More serious questions surround other cancers — like which men, if any, should get a PSA blood test to check for prostate cancer, and whether women should start mammograms in their 40s or wait until they're 50.

Also in question is whether doctors will be able to head off another looming controversy: Just which smokers and ex-smokers should get a pricey CT scan that can detect lung cancer but also is prone to false alarms? A recent study found the scans could save some lives. But guidelines aren't due out until early next year that would decide who is at enough risk to outweigh the test's potential harm — such as a risky, invasive biopsy to tell if a suspicious spot is cancer or just an old smoking scar.

Yet already people like 80-year-old Fred Voss of Sunderland, Md., are seeking out the tests.

"It was a big relief, and it gave me something to watch," says Voss, who participated in the CT study but wanted to get tested again to make sure nothing had changed.

Today, guidelines for how to handle some of the most common cancer screenings conflict. And, they're written for the average patient when many people may need a more customized decision, says Dr. Jeanne Mandelblatt of Georgetown University. She has studied breast cancer risk for a government panel that recommends most women not begin screening for the disease until age 50.

Consider this, she says: The average woman has a 3 percent lifetime risk of dying of breast cancer, a low risk for a disease that women find so scary. But the chances of getting breast cancer do gradually increase with age and other circumstances.

So if you're 40 and have several risk factors — like dense breasts and close relatives with the disease — then you have the same risk as an average 50-year-old, not an average 40-year-old, and might consider earlier mammograms, Mandelblatt says. Few primary-care doctors have the time to go into that kind of detail.

Adding to the confusion are testimonials from cancer survivors that a screening saved their lives. Dartmouth researchers recently studied how often that's true for mammograms, and estimated that about 13 percent of women in their 50s whose breast cancer is detected by the tests survive as a result.

What else plays a role? Treatments have dramatically improved in recent years, saving more lives. Also, increasingly powerful mammograms are detecting more low-risk tumors, the kind that probably wouldn't have threatened a woman's life in the first place.

Still, mammograms are "not perfect, but they're the best we have," cautions Mandelblatt. She thinks the Dartmouth estimate is somewhat low.

PSA tests for prostate cancer are a much tougher call. Last month, a government panel recommended an end to routine PSA screenings, a step further than other major medical groups that urge men to weigh the pros and cons and decide for themselves. But the U.S. Preventive Services Task Force found limited, if any, evidence that screening average men improves survival. That's largely because so many men are diagnosed with slow-growing tumors that never would have killed them; still, they have treatments that can cause incontinence, impotence or even lead to death.

"We really — underline the word 'really' — have to pull back the messaging on prostate cancer," says the cancer society's Lichtenfeld, who himself isn't sure of the test's net worth. PSA testing took off on the basis of "blind faith" that they would work, not science, he says.

What really worries Lichtenfeld is that ever more powerful cancer screenings are being developed, before doctors have a way to tell exactly which early tumors should be removed.

"We have cells in our body that are abnormal all the time, and our bodies deal with it," he says. "Our technology takes us further and further down the early-detection path, and we need to sort through all this."

___

EDITOR'S NOTE — Lauran Neergaard covers health and medical issues for The Associated Press.

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Sabtu, 29 Oktober 2011

Lung cancer screening with X-rays isn't beneficial

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CHICAGO (AP) — Routine chest X-rays do not prevent lung cancer deaths, not even in smokers or former smokers, according to a big government study challenging a once common type of screening.

In the study of more than 150,000 older Americans, those who had four annual chest X-ray screenings were just as likely to die of lung cancer as participants who didn't have those tests.

The results from the National Cancer Institute-funded research confirm previous, smaller X-ray studies. They follow another big study from that institute favoring a newer, more sophisticated imaging test. That found fewer lung cancer deaths among current or former heavy smokers who had special CT imaging scans versus those who had chest X-rays.

CT scans provide much more detailed images than X-rays, and while no major medical group recommends any type of routine lung cancer screening, several are preparing new guidelines.

Screening refers to routine tests in people without symptoms; doctors say chest X-rays are still useful to help diagnose people with lung cancer symptoms, including a persistent cough or coughing up blood.

Chest X-ray screening for lung cancer was common decades ago, and some doctors continue to recommend it in smokers and former smokers. The new study results should put an end to that practice, said Robert Smith, director of cancer screening at the American Cancer Society.

"No one recommends it but they do occur quite a lot," said Smith, who was not involved in the study.

The study was released online in the Journal of the American Medical Association on Wednesday, when it was presented at an American College of Chest Physicians meeting in Hawaii. The doctors' group is among those preparing new lung cancer screening recommendations.

The study's participants were aged 55 to 74 and were tracked for about 13 years. During that time, there were about 1,200 lung cancer deaths in participants who got X-rays and in those who got usual medical care. That's equal to about 14 deaths per 10,000 people each year.

Lung cancer is the leading cancer killer; it will be diagnosed this year in about 220,000 people nationwide, and more than half that number will die from lung cancer, the cancer society estimates.

Less than 1 percent of never smokers will develop lung cancer in their lifetime. By contrast, about 18 percent of current smokers will get the disease by age 75; the risk is somewhat lower but not zero for former smokers, depending on how long ago they quit, said Dr. Christine Berg, the study's senior author and chief of the National Cancer Institute's early detection research group.

"We were really hoping chest X-rays might be beneficial," partly because they are relatively inexpensive — about $60 versus hundreds and sometimes thousands of dollars for CT scans, Berg said.

But Smith said the study shows routine chest X-ray screenings in healthy people without symptoms are "a waste of time," plus they can lead to false-positive results that may lead to invasive and potentially harmful tests.

Similar concerns have been raised recently about too-frequent pap tests for cervical cancer, routine PSA tests for prostate cancer screening, and excessive mammograms for breast cancer, leading to revised guidelines from the U.S. Preventive Services Task Force.

That independent group, which advises the U.S. government, concluded in 2004 that there was no evidence to support any method of routine lung cancer screening in people without symptoms, including X-rays and CT scans.

It is updating those guidelines based on recent new evidence, including last year's CT scan vs. chest X-ray study, and will take into account the new X-ray study, too, said Dr. Michael LeFevre, co-vice chairman of the task force and a family physician at the University of Missouri. That process may take up to two years, he said.

Because CT scans also can yield false positive results, it is unlikely any group will recommend them for screening nonsmokers.

___

Online:

JAMA: http://www.jama.ama-assn.org

National Cancer Institute: http://1.usa.gov/cndLsL

___

AP Medical Writer Lindsey Tanner can be reached at http://www.twitter.com/LindseyTanner

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Minggu, 23 Oktober 2011

Annual cancer screening tests urged less and less

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Annual cancer tests are becoming a thing of the past. New guidelines out Wednesday for cervical cancer screening have experts at odds over some things, but they are united in the view that the common practice of getting a Pap test every year is too often and probably doing more harm than good.

A Pap smear once every three years is the best way to detect cervical cancer, the U.S. Preventive Services Task Force says. Last week, it recommended against prostate cancer screening with PSA tests, which many men get every year.

Two years ago, it said mammograms to check for breast cancer are only needed every other year starting at age 50, although the American Cancer Society still advises annual tests starting at age 40. Earlier this week, a large study found more false alarms for women getting mammograms every year instead of every other year.

"The more tests that you do, the more likely you are to be faced with a false-positive test" that leads to unnecessary biopsies and possible harm, said Dr. Michael LeFevre, one of the task force leaders and a professor of family and community medicine at the University of Missouri. "We see an emerging consensus that annual Pap tests are not required for us to see the benefits that we have seen" from screening, he said.

Those benefits are substantial. Cervical cancer has declined dramatically in the United States, from nearly 15 cases for every 100,000 women in 1975 to nearly 7 per 100,000 in 2008. About 12,200 new cases and 4,210 deaths from the disease occurred last year, most of them in women who have never been screened or not in the past five years.

New proposed guidelines from the cancer society and other groups say using Pap smears together with tests for HPV, the virus that causes cervical cancer, every three to five years is the preferred way to screen women ages 30 to 65. But the government task force concluded the evidence is insufficient "to assess the balance of benefits and harms" of that.

Instead, more lives probably could be saved by reaching women who are not being adequately screened now, the task force says.

And despite what many people suspect, cost has nothing to do with the task force's stance, its leaders said.

"We don't look at cost at all. We really are most concerned about harms," said Dr. Evelyn Whitlock of Kaiser Permanente Northwest's Center for Health Research in Portland, Ore., who led an evidence review for the task force.

Here are some questions and answers about the cervical cancer guidelines.

Q. At what ages should screening start and end?

A. The task force recommends against screening women under 21 or older than 65. Very few cervical cancer cases occur in women under 21, so the old advice to start screening three years after the age of first intercourse has been changed. HPV tests are only approved for women after age 30 because transient infections that don't pose a cancer risk are more common at younger ages.

"We should not be screening teenagers. It's not helping, it's not finding any more cancers and it's creating way too many harms for them," said Debbie Saslow, the cancer society's director of breast and gynecologic cancer.

Q. Should anyone else not be screened?

A. Women who have had their cervix and uterus removed should not be tested, but check with your doctor — not all hysterectomies are complete; some leave the cervix.

Q. What does screening cost?

A. Paps cost $15 to $60; HPV tests run $50 to $100.

Q. Will insurance pay for HPV tests since the government panel doesn't endorse them?

A. Probably. They are included in preventive services that other federal advisers say should be covered under the Affordable Care Act, and the government has continued to pay for mammograms for women who want them even if it is sooner or more often than the task force recommends.

Q. What if I've had the HPV vaccine?

A. Doctors don't know how the vaccine will affect HPV test results or how long the vaccine lasts, so women should still be screened for cervical cancer if they are within the recommended screening ages.

Q. How can I comment on the guidelines?

A. The web sites below tell how. Comments are accepted for a month before guidance is adopted.

___

Online:

Task force advice: http://www.uspreventiveservicestaskforce.org/

Cancer society advice: www.asccp.org/practice-management/molecular-screening-symposium

and http://tinyurl.com/44gnadx

and http://tinyurl.com/257mnge

Cervical cancer science review: http://tinyurl.com/6lc2rzg

CDC on HPV tests: http://www.cdc.gov/hpv/Screening.html

___

Marilynn Marchione can be followed at http://twitter.com/MMarchioneAP

Associated Press

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Jumat, 21 Oktober 2011

Annual cancer screening tests urged less and less

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Annual cancer tests are becoming a thing of the past. New guidelines out Wednesday for cervical cancer screening have experts at odds over some things, but they are united in the view that the common practice of getting a Pap test every year is too often and probably doing more harm than good.

A Pap smear once every three years is the best way to detect cervical cancer, the U.S. Preventive Services Task Force says. Last week, it recommended against prostate cancer screening with PSA tests, which many men get every year.

Two years ago, it said mammograms to check for breast cancer are only needed every other year starting at age 50, although the American Cancer Society still advises annual tests starting at age 40. Earlier this week, a large study found more false alarms for women getting mammograms every year instead of every other year.

"The more tests that you do, the more likely you are to be faced with a false-positive test" that leads to unnecessary biopsies and possible harm, said Dr. Michael LeFevre, one of the task force leaders and a professor of family and community medicine at the University of Missouri. "We see an emerging consensus that annual Pap tests are not required for us to see the benefits that we have seen" from screening, he said.

Those benefits are substantial. Cervical cancer has declined dramatically in the United States, from nearly 15 cases for every 100,000 women in 1975 to nearly 7 per 100,000 in 2008. About 12,200 new cases and 4,210 deaths from the disease occurred last year, most of them in women who have never been screened or not in the past five years.

New proposed guidelines from the cancer society and other groups say using Pap smears together with tests for HPV, the virus that causes cervical cancer, every three to five years is the preferred way to screen women ages 30 to 65. But the government task force concluded the evidence is insufficient "to assess the balance of benefits and harms" of that.

Instead, more lives probably could be saved by reaching women who are not being adequately screened now, the task force says.

And despite what many people suspect, cost has nothing to do with the task force's stance, its leaders said.

"We don't look at cost at all. We really are most concerned about harms," said Dr. Evelyn Whitlock of Kaiser Permanente Northwest's Center for Health Research in Portland, Ore., who led an evidence review for the task force.

Here are some questions and answers about the cervical cancer guidelines.

Q. At what ages should screening start and end?

A. The task force recommends against screening women under 21 or older than 65. Very few cervical cancer cases occur in women under 21, so the old advice to start screening three years after the age of first intercourse has been changed. HPV tests are only approved for women after age 30 because transient infections that don't pose a cancer risk are more common at younger ages.

"We should not be screening teenagers. It's not helping, it's not finding any more cancers and it's creating way too many harms for them," said Debbie Saslow, the cancer society's director of breast and gynecologic cancer.

Q. Should anyone else not be screened?

A. Women who have had their cervix and uterus removed should not be tested, but check with your doctor — not all hysterectomies are complete; some leave the cervix.

Q. What does screening cost?

A. Paps cost $15 to $60; HPV tests run $50 to $100.

Q. Will insurance pay for HPV tests since the government panel doesn't endorse them?

A. Probably. They are included in preventive services that other federal advisers say should be covered under the Affordable Care Act, and the government has continued to pay for mammograms for women who want them even if it is sooner or more often than the task force recommends.

Q. What if I've had the HPV vaccine?

A. Doctors don't know how the vaccine will affect HPV test results or how long the vaccine lasts, so women should still be screened for cervical cancer if they are within the recommended screening ages.

Q. How can I comment on the guidelines?

A. The web sites below tell how. Comments are accepted for a month before guidance is adopted.

___

Online:

Task force advice: http://www.uspreventiveservicestaskforce.org/

Cancer society advice: www.asccp.org/practice-management/molecular-screening-symposium

and http://tinyurl.com/44gnadx

and http://tinyurl.com/257mnge

Cervical cancer science review: http://tinyurl.com/6lc2rzg

CDC on HPV tests: http://www.cdc.gov/hpv/Screening.html

___

Marilynn Marchione can be followed at http://twitter.com/MMarchioneAP

Associated Press

Technology



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Sabtu, 08 Oktober 2011

Panel Advises Against Routine Prostate Screening

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Visuals Unlimited, Inc. / Dr. Gladden Willis / Getty Images Visuals Unlimited, Inc. / Dr. Gladden Willis / Getty Images

No major medical group recommends routine PSA blood tests to check men for prostate cancer, and now a government panel is saying they do more harm than good and healthy men should no longer receive the tests as part of routine cancer screening.

The panel's guidelines had long advised men over 75 to forgo the tests and the new recommendation extends that do-not-screen advice to healthy men of all ages.

The recommendation by the U.S. Preventive Services Task Force, being made public on Friday, will not come as a surprise to cancer specialists.

Yet, most men over 50 have had at least one PSA blood test, the assumption being that finding cancer early is always a good thing.

Not so, said Dr. Virginia Moyer of the Baylor College of Medicine, who heads the task force.

"We have put a huge amount of time, effort and energy into PSA screening and that time, effort and energy, that passion, should be going into finding a better test instead of using a test that doesn't work," Moyer told The Associated Press late Thursday.

Too much PSA, or prostate-specific antigen, in the blood only sometimes signals prostate cancer is brewing. It also can mean a benign enlarged prostate or an infection. Worse, screening often detects small tumors that will prove too slow-growing to be deadly. And there's no sure way to tell in advance who needs aggressive therapy.

MORE: Saw Palmetto No Better Than Placebo for Prostate Symptoms

The task force analyzed all the previous research on this subject, including five major studies, to evaluate whether routine screening reduces deaths from prostate cancer. The conclusion: There's little if any mortality benefit.

But there is harm from routine screening: impotence, incontinence, infections, even death that can come from the biopsies, surgery and radiation, Moyer said.

One study estimated 2 of every 5 men whose prostate cancer was caught through a PSA test had tumors too slow-growing to ever be a threat.

Yet Moyer said 30 percent of men who are treated for PSA-discovered prostate cancer suffer significant side effects, sometimes death, from the resulting treatment.

About a third of men ages 40 to 60 have brewing prostate cancer but "the huge majority of them will never know it in their lifetime if they are not screened," she added.

MORE: Screening for Ovarian Cancer Doesn't Increase Women's Survival

The task force previously had considered the evidence for or against PSA screening inconclusive. The new recommendation says not to routinely screen. That recommendation is a draft that is open for public comment beginning next week.

"We have been long concerned, and it has been apparent for some years, that some supporters of prostate cancer screening have overstated, exaggerated and in some cases misled men about the evidence supporting its effectiveness," said Dr. Otis Brawley of the American Cancer Society in a statement. "We need balanced, truthful information to be made widely available to physicians and patients when making important health decisions."

The society had not seen the new recommendation yet, but has long advised men to consider the pros and cons of PSA screening before deciding on their own.

Moyer said the recommendation only means that doctors shouldn't bring up the option for healthy men. If a man asks for a PSA test and wants it after being informed of the evidence, he should receive it, she said. Likewise, it's appropriate to use PSA tests to examine a man with possible prostate symptoms.

—By LAURAN NEERGAARD



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Jumat, 07 Oktober 2011

Prostate Cancer Screening: What You Need to Know

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A panel of cancer experts is recommending against testing for prostate-specific antigen (PSA), the most commonly used prostate cancer screen, in healthy men.

According to its review of the best available data, the U.S. Preventive Services Task Force (USPSTF) concludes that the potential harms of PSA testing — which include further, more invasive testing that may result in impotence and incontinence — outweigh any benefits in healthy men. The panel is expected to release on Tuesday a comprehensive report detailing the value of PSA testing, but the group's draft recommendation was made public this week.

What does this mean for men who are concerned about prostate cancer? Here's some information that can help you decide whether it's right for you.

What is the PSA test?

The PSA test is a blood test that measures levels of prostate-specific antigen, a protein produced by cells of the prostate gland. It tends to show up on cancer cells, so higher levels of the antigen could be a sign of tumors. Men normally have low levels of PSA, but those levels may rise for reasons unrelated to cancer, which is why a high PSA level alone cannot be used to determine whether a man has cancer or some other benign condition.

What conditions other than prostate cancer can raise PSA levels?

There are many: benign growth of the prostate (the gland typically enlarges with age), infection or inflammation of the prostate, ejaculation, and riding a bicycle can all push PSA levels higher.

Who should get the PSA test?

Currently, there is no major medical group that recommends routine PSA testing, but millions of men over age 50 get it. The American Cancer Society, for example, does not have a specific recommendation for routine screening of healthy men without symptoms of prostate cancer, but it advises otherwise healthy men who have reason for concern about increased prostate risk to begin discussing screening with their doctors at age 50. That's because the risk of prostate cancer tends to increase with age.

MORE: Saw Palmetto No Better Than Placebo for Prostate Symptoms



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Jumat, 30 September 2011

Does sex matter in colon cancer screening?

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By Frederik Joelving

NEW YORK | Wed Sep 28, 2011 5:05pm EDT

NEW YORK (Reuters Health) - Middle-aged men are twice as likely as women to end up with a cancer diagnosis after colonoscopy, according to an Austrian study that challenges screening guidelines.

Guidelines currently advise that people at average risk of colon cancer start screening for the disease at age 50, regardless of gender.

But the new work, published in the Journal of the American Medical Association, shows a discrepancy of nearly 10 years between men and women in the development of colon and rectal tumors.

That means the same number of 55-year-old men would need to undergo colonoscopies -- in this case, around 80 -- to spot one cancer, as would be true for 65-year-old women. The same logic held true for the pre-cancerous growths called advanced adenomas, which doctors also scout for during colonoscopies.

However, a U.S. expert warned about making decisions regarding when to start screening based on the new findings.

"I would discourage women from looking at this study and saying, 'Gee, I can wait longer,'" said Dr. Michael LeFevre of the U.S. Preventive Services Task Force, a federally supported expert panel. "And I would discourage men from saying, 'Gee, I should start sooner.'"

The USPSTF recommends colon cancer screening between the ages of 50 and 75 using one of a number of types of tests. The advantage of colonoscopy, which costs around $3,000, is that it only has to be repeated once every ten years, as opposed to every year for the much cheaper stool test.

About one in 19 men develops colon cancer at some point and slightly fewer women do. The disease, which usually strikes older adults, is the third leading cause of cancer deaths in the U.S.

To get a better idea of when to start screening, Dr. Monika Ferlitsch and her colleagues looked at data from more than 44,000 Austrians, who'd had colonoscopies between 2007 and 2010.

Overall, they found 25 percent of men had adenomas, compared to only 15 percent of women. For full-blown tumors, those numbers were 1.5 percent and 0.7 percent, respectively.

At 0.8 percent, the rate of colon cancer among men aged 50 to 54, for instance, was twice that found among women in the same age group. That means 125 men would need to have a colonoscopy to find one tumor, versus 264 women.

While the reasons for the difference are still murky, Ferlitsch, of the Medical University of Vienna, said it could be linked to a higher degree of overweight and fatty liver disease among men -- both of which have been linked to colon cancer.

While her team suggests "screening recommendations concerning age should be reconsidered," Ferlitsch wasn't ready to give practical advice.

"It's a difficult question if we should delay screening in women or start it earlier in men," she told Reuters Health.

LeFevre said the USPSTF will take the new results into consideration as the panel updates its guidelines over the next couple of years.

Meanwhile, he told Reuters Health, "I think people can safely stick with the recommendation on the table to start screening at age 50, whether they are a man or a woman."

SOURCE: bit.ly/ox7Dtb Journal of the American Medical Association, September 27, 2011.



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