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Tampilkan postingan dengan label Miscarriage. Tampilkan semua postingan
Tampilkan postingan dengan label Miscarriage. Tampilkan semua postingan

Jumat, 14 Oktober 2011

Guidelines of the ultrasound can diagnose wrongly miscarriage

As if anxiety about potential error were not quite stressful for newly pregnant women, research published Friday shows that the current guidelines for using ultrasound to determine that a pregnancy is completed can not always be accurate.

Four new studies looked at ultrasound U.K. specifications, but when the results are extrapolated to the guidelines of the U.S., researchers suggest that 1 in 23 women diagnosed with error could still have a viable pregnancy.

That could mean for the future of such incorrectly doomed pregnancies is not known. Researchers analyzed not if women in the studies that have been informed that their pregnancies had ended then has to have surgery to remove their uterus.

But just the possibility that a pregnant woman unintentionally would end a pregnancy viable is intolerable, said Tom Bourne, Professor of Gynecology at Imperial College London and principal author of three related studies published in the journal ultrasound in obstetrics and Gynecology. "We are concerned that the current guidelines can lead to a misdiagnosis," said Bourne. "The current thresholds for error are not appropriate."

More: Women Grieve error for years, even after having a healthy baby

Ultrasound is the gold standard used to determine the error. It is assumed - at least by pregnant women - exceptionally precise. Yet, studies, who analysed the existence or the size of the gestational sac, concluded that the presence or absence of a gestational sac, as well as its size, were not infallible indicators of spontaneous abortion.

The researchers followed 1,060 women who complained of slight bleeding or pain - the two potential signs that a pregnancy is distressed - between five and eight weeks of pregnancy and had an initial ultrasound. As is practical, they returned seven to ten days later for a further analysis measure the growth of the bag. Those who were still pregnant were followed again between 11 and 14 weeks.

Generally, an embryo enjoyed 6 mm with no increase in the size of the gestational sac between detectable scans or without a heartbeart is supposed to indicate the spontaneous abortion, but Bourne concluded that it is possible that a pregnancy may not grow measurable in a week. In fact, half a percentage point for women in the study - or 1 in 183 - still could be pregnant even if scanning guidelines technically would have classified their pregnancies in the end.

To the United Kingdom, ultrasounds which reveal an empty gestational sac over 20 mm in size lead to a diagnosis of spontaneous abortion. In the United States, the standard established by the American College of Radiology is 16 mm. based on the findings of researchers, 8 in 183 U.S. women - or 1 to 23 - would have a miscarriage diagnosed incorrectly.

More: The common use Painkiller may be linked to the risk of miscarriage

Another study concluded that a gestational sac can vary up to 20% according to the who made the measure; different clinicians obtain different results. Imagine, for example, that a Sonographer overstates size of CCS, and then a second ultrasound later underestimates it. The confusion which could lead to a women being falsely that she had failed.

To increase the precision, Bourne recommends ultrasound guidelines be updated and increased standards for the determination of miscarriage.

Jonathan Schaffir, Associate Professor of obstetrics and Gynecology at the Ohio State University, who was not involved in the research, said that the British studies are important, even if it is likely that most of the doctors who suspect miscarriage at early stages of pregnancy would adopt a wait-and-see approach. "It is important of Miss not even a viable pregnancy, but it is rather unusual to determine the error based on an analysis of these measures at the beginning, at the beginning," he said. "From a practical point of view, the results of these studies will not change clinical practice."

Bonnie Rochman is a journalist in time. Find him on Twitter at @ brochman. You can also continue the discussion on the time Facebook page and Twitter time @.



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Miscarriage diagnoses questioned

AppId is over the quota
AppId is over the quota
14 October 2011 Last updated at 00:11 GMT By James Gallagher Health reporter, BBC News Some pregnancies are being terminated unnecessarily after an incorrect diagnosis of miscarriage, say doctors.

They say there is too much room for error in ultrasound scans in the first six weeks, which wrongly label a small percentage of embryos as miscarried.

The true scale of the problem is unknown but researchers said it was "hard to see how there can't be women having misdiagnoses being made".

Guidelines are currently being reviewed.

The study suggested the current rules "could lead to 400 viable pregnancies potentially being misclassified", however the researchers said this was an educated guess with no evidence of how many would lead to a termination.

'More cautious'

Miscarriage is very common, affecting one in five pregnancies.

If a women experiences pain or bleeding early in the pregnancy, around five to six weeks, they will have an ultrasound scan.

Two results would suggest a miscarriage, which could then lead to a decision to terminate the pregnancy:

an embryo greater than 6mm in length, but without a heartbeata pregnancy sac greater than 20mm, but with no visible embryo

A series of papers published in Ultrasound in Obstetrics and Gynaecology questioned the thresholds.

One paper reviewed the evidence for the guidelines and said they were based on poor evidence.

Another reported significant variation in the measurements made by different clinicians, which could in theory change the diagnosis.

Tests on 1,060 women whose pregnancy was in question showed the 20mm rule would diagnose about 0.5% of cases as miscarriages when they were in fact healthy.

Prof Tom Bourne, from Imperial College London, told the BBC: "We found that the cut-off values were not entirely safe because they can be associated with a misdiagnosis of miscarriage in a small number of cases, and our view is that there shouldn't be any risk.

"I think a significant number is one, frankly. I think anyone who has a diagnosis of miscarriage and potentially has surgery would expect that that diagnosis is right."

He argues the cut-offs should be about 25mm instead of 20mm for the sac and 7mm for an embryo without a heartbeat. He also wants a greater emphasis on repeat scans.

He said: "There's not a medical cost to being more cautious in what we're doing."

New guidelines

Prof Siobhan Quenby, from University Hospital Coventry, welcomed greater attention and clarity on the issue, but said: "I really don't think many mistakes are being made."

She said people were aware of issues with the guidance and if there was any doubt, further tests, not a termination, would take place.

It is "very common that people come back for a second scan", she said.

For those with a miscarriage diagnosis, she said that in the majority of cases there would be no medical intervention. About 30% would take tablets or have surgery to end the pregnancy.

Dr Mark Hamilton, consultant gynaecologist at Aberdeen Maternity Hospital, said the findings "reinforce the need for clinical staff to continue to exercise great care in the diagnosis of non-viable pregnancy to minimise the risk of misdiagnosis.

"Women should continue to be managed expectantly without the need for medical treatment or surgery until the diagnosis of non-viability is established with certainty."

The National Institute for Health and Clinical Excellence is currently developing guidelines for the care of women who experience pain and bleeding in early pregnancy. There is already guidance available from the Royal College of Obstetricians and Gynaecologists.

This will include the role of ultrasound in determining the viability of a pregnancy and will draw on this research. New guidelines are due in November 2012.

The Royal College of Obstetricians and Gynaecologists welcomed the studies.



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