HEALTH MANAGEMENT. Protective protein prevents joints ravaged immune system from and bones in rheumatoid arthritis

Researchers at the Northwestern University Feinberg have discovered School of medicine, why the immune cells of patients with rheumatoid arthritis are hyperactive and attack the joints and bones. The immune cells have lost their bouncer, burly protein, which is the same way keeps them in line, that noisy patrons controls a bouncer at a nightclub.
The Feinberg School team has this bouncer, a protein called P21, which prevents the immune cells are start in their destructive rampage through the cartilage and bone. If she developed scientists and injected an imitation of the protein in an animal model of rheumatoid arthritis, the disease process was stopped.
"The doorman molecule immune cells of crazy, not more", said lead author Harris Perlman, Associate Professor of Rheumatology at the Northwestern Feinberg School. "Imagine destructive customers in a bar and Bouncer says: 'You're going to behave!'" P21 is. "This discovery opens up a new avenue for future therapies, heavily used against rheumatoid arthritis."
Feinberg team in P21 showed previous studies on patients with rheumatoid arthritis were low, but the protein role was unknown. The new study, published in the journal Arthritis & rheumatism, shows role crucial protein, to keep the immune cells in check.
Currently said to stop, Perlman hyperactive immune cells can be not effective, non toxic.
To develop the new approach, tested share five different Perlman and his team, peptides, called by P21. He slipped each peptide in a "ghostly" molecule, which he injected into mice with rheumatoid arthritis-like disease. The molecule secretly infiltrated the immune cells. After the seven day trial, one of the tested peptides had reassured the overactive immune cells without toxic effects. Next, Perlman plans a 30-day trial of the same peptide to monitor effectiveness and toxicity over a long period.
Existing treatments for rheumatoid arthritis are low-level chemotherapy and corticosteroids. These are not always effective, however, and they are often accompanied by side effects. A newer class of therapy, sometimes used in combination with chemotherapy and steroids, is a biological response modifier. These are the antibody or other proteins that are produced from the hyperactive immune cells to reduce the inflammation. These Biologics work not for everyone, however, and can be associated with side effects, including the risk of infection.

Posted in: arthritis,bones,immune,joints,prevents,Protective,protein,ravaged,rheumatoid,system