HEALTH MANAGEMENT. Created set of mammalian cells with single chromosome.

Researchers have mammalian cells using a single set of chromosomes for the first time in research, created by the Wellcome Trust and EMBO. The technology should enable that scientists better establish the relationship between genes and their function.
Mammal cells contain usually two sets of chromosomes - the mother, an inherited from the father set. The genetic information in this chromosome sets, that helps to determine how our bodies to develop. Changes in the genetic code can cause that or increase the risk of diseases.
To understand how our genes function, scientists manipulate the genes in animal models - how fly, zebrafish and mice - and watch the impact of these changes. As each cell contains two copies of each chromosome, the connection between genetic changes and their physical effects or 'Phenotype' - determination is immense but complex.
Now, in research worship and Martin Leeb of the Wellcome Trust Centre published in the journal nature, DRS Anton for stem cell research at the University of Cambridge report a technique, the stem cells, which can create only a single set of chromosomes from a mouse unfertilized egg. The stem cells can be used to identify mutations in genes, that of cells affect behaviour in culture. In a further step, the cells can be implanted into the mouse for the analysis of a change in organs and tissues may.
The technique was used previously in zebrafish, but this is the first time that it was successfully used to generate such mammalian stem cells.
Dr. pig, Wellcome Trust senior research fellow, explains: "these embryonic stem cells are much simpler than normal mammalian embryonic stem cells." All genetic changes that we introduce to the single set of chromosomes is simply to determine impact. "This will be useful to the explore systematically signalling mechanisms within the cell and as networks of genes regulate development."
The researchers hope that this technique advance mammal genetics and our understanding of gene function relationship in the same way that a similar technique geneticists understand simple zebrafish animal model has helped.
Understand how our genetic makeup functions and how this knowledge can be applied to improve our health by the Wellcome Trust is one of the most important strategic challenges. This new study, Dr. Michael Dunn, Director of the molecular and physiological of Sciences, the Wellcome Trust, says:
"This technology will help scientists some significant obstacles to overcome, so far the functions of genes, to study so hard." "This is often the first step to understand why mutations lead to disease and ultimately to new treatments."

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