Jumat, 09 September 2011

HEALTH MANAGEMENT. Individual 'errors' in connection with Parkinson's mechanism for the conversion of a cell affects genetic code in proteins

Less than two months after publication of results of Parkinson's a new genes for late onset disease, have linked the same team of scientists at the University of British Columbia and Vancouver Coastal Health Research Institute for the neurodegenerative disease - which still aim for potential treatments an another gene discovered. HEALTH MANAGEMENT

The mutation, a "typo" under three billion nucleotides in DNA, lays down the mechanism for the conversion of a cell genetic code into proteins. The results are published journal of human genetics in the American.
The mutation, EIF4G1, was found in a family from France, has a high rate of the disease--more than half of the members of each generation develop. TESCO HEALTH INSURANCE
The lead researchers on the study, Matthew Farrer, Professor in the Department of medical genetics and Canada Excellence Research Chair in neurogenetics and translational Neuroscience at UBC, says, that if the location of the mutation was discovered, and it determines which conditions it affected, "Very much at first does not make sense." HEALTH INFORMATION TECHNOLOGY

"A gene in a protein to translate a such basic operation to the life of a cell," says Farrer, of the Dr. Donald RIX b.c. leadership Chair of genetic medicine was named last week. "I thought it would probably be not to this form of Parkinson's disease, lead, appears later in the life of an individual, and relates to only a small subset of brain cells."
But Farrer, Member of the brain research centre at UBC and Vancouver Coastal Health Research Institute, realized that this particular protein translation is important only if the cell is confronted by some kind of stress - for example a lack of oxygen and nutrients. WPA HEALTH INSURANCE

In addition, the protein specifically regulates the cell reuse capability, its own components. Parkinson, contains an important link to disease because a hallmark of Parkinson's the presence of "Lewy bodies is" - collections of discarded proteins which remain, that in certain brain cells caught.
More than 100,000 Canadians, about one million Americans and more than 10 million people worldwide are affected by Parkinson's disease. Symptoms include trembling in hands, arms, legs and face, rigidity in the limbs and torso, as well as slow movement and poor balance and coordination. There is currently no cure, and most treatments only combat the symptoms.
"This discovery provides direct evidence that can result in Parkinson's disease by gene - environmental interactions," says Farrer. "The resulting impairment underlines neural recycling systems as the focal point in efforts to develop a more effective drugs." AHM HEALTH INSURANCE

The genetic samples obtained through cooperation with researchers of the Université Lille Nord de France, began in 1998. Much of the work in the laboratory was performed while Farrer at the Mayo Clinic in Jacksonville, Florida worked.
The majority of the support for the research came from the French Government and the US national institutes of health.

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