HEALTH MANAGEMENT. Data show that fragile X-associated tremor/ataxia syndrome with defective neuronal RNA transport can be connected

SUNY Downstate scientist Ilham Muslimov, MD, PhD, together with the senior author Henri Tiedge, PhD, Professor of Physiology and Pharmacology and neuroscience, published a study suggesting that associated with the cellular dysregulation certain neurodegenerative diseases caused by molecular competition neural RNA transport means.HEALTH MANAGEMENT

The paper appeared in the journal of cell biology, titled "spatial code recognition in neural RNA-targeting: the RNA HnRNP A2 roll interactions." The article was stressed in an accompanying editorial, "RNA-targeting will be competitive." TESCO HEALTH INSURANCE

Dr. Tiedge notes, "in contrast to DNA, can in what information encoding is one-dimensional (i.e., linearly), in three-dimensional architectural motifs encode RNA information." "Dr. Muslimov has now identified RNA motifs that serve as spatial codes in nerve cells, directed by RNA dendrites and synapses." A Synapse is a cross, to be able to pass the a neuron (neuron) an electrical or chemical signal to another cell, and dendrites are branched neurons, that Act, electrochemical stimulation, to carry out neuronal cell body.
He adds: "as number 7 in a New York u-Bahn train a code for the target ' Times Square', Dr. Muslimov RNA motifs code Dendrite and Synapse objectives for that." "They shall ensure that RNAs to cellular pages are delivered, where they are to work." HEALTH INFORMATION TECHNOLOGY

"Sometimes, a RNA expressions can an unreasonably high number of goals motives, with the result that the resources of the transport system are overwhelmed." It is at the same time trains as if give too many passengers to exceed system capacity. "We have traffic jams and traffic is interrupted."
Dr. Tiedge explains that Dr. Muslimov work indicates that dendritic delivery of RNA can result in nerve cells, excessive competition for general transport resources in vulnerable. "In the example, who studied the Dr. Muslimov, the culprit is a RNA, the genetic information for the fragile X mental retardation protein contains." "As soon as the number of motifs exceeds a threshold (usually around 55) structures in this RNA, the RNA is overly competitive and begins at the expense of other RNAs, common resources of cellular transport system to take over." WPA HEALTH INSURANCE

"Dr. Muslimov data increase the possibility that the resulting neurodegenerative disease, the fragile X-associated tremor/ataxia syndrome due to a neuronal transport problem is accelerated," concludes Dr. Tiedge. AHM HEALTH INSURANCE

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