It is difficult to think that bacteria as good when it comes to health, but research shows more bugs that live in our intestines can have great influence on our well-being. In a new study, scientists found that these bugs can affect how patients respond to save the life of drugs such as statins.
Statin drugs may help lower cholesterol levels and reduce the risk of heart disease and stroke in people who take their. But not every patient benefits from drugs, and doctors had no good explanation why.
Now, report researchers in the journal PLoS One that the answer may lie with our intestinal bacteria. These bugs typically live in our intestines and are working to digest and break down the food we eat. But recently, scientists have learned that their impact goes even further; also, they produce vitamins, help the immune system and may affect all our weight to how metabolize us drugs.
In the new study of 100 people, researchers found that those whose LDL, or bad cholesterol, abandoned most after taking simvastatin statin drugs (Zocor) for six weeks have also had higher levels of three bile acids by intestinal bacteria, compared with those whose LDL is not decline as much. Persons who have not responded to simvastatin showed higher levels of five other bile acids by intestinal flora.
Why the difference in drug response? Researchers believe that five compounds made by poor stakeholders imitate statins and therefore compete with the drug in binding to the appropriate cells. Thus, after having too much of these means of bile acids which Statin molecules cannot obtain the cells of the liver where they would be regulating the production of cholesterol.
"We found that the benefit of Statins may be in part related to the type of bacteria in our guts," co-author of the study Rima Kaddurah-Daouk, Professor of Psychiatry at Duke University, said in a statement. "The reason for which that respond us differently is not only our genetic heritage, but also our gut microbiome."
This means that it might be possible to test people until they begin to take some Statins whether who will respond and which not. Blood tests can detect bile acids which can compete with simvastatin, so that people who have high levels may be directed to the different Statins which can better control their cholesterol levels.
There is also the possibility of changing the landscape of the intestinal flora by consuming probiotics, to promote colonies of bacteria which counter the effects of statins. Certain yogurts and other probiotic foods already are trying to take advantage of this beneficial intestinal flora to stimulate well-being through other means. "We are at a stage very early to understand this relationship, but [is] is no doubt that metabolites of bacteria play an important role in the regulation of our systems," said Kaddurah-Daouk. And perhaps help us to better health.
Alice Park is a writer in time. Find him on Twitter at @ aliceparkny. You can also continue the discussion on the time Facebook page and Twitter time @.
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